14-Aminotetradecanoic acid exhibits antioxidant activity and ameliorates xenobiotics-induced cytotoxicity
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Title |
14-Aminotetradecanoic acid exhibits antioxidant activity
and ameliorates xenobiotics-induced cytotoxicity
|
|
| Creator |
Anup, Srivastava
Jagan Mohan Rao, L. Shivanandappa, T. |
|
| Subject |
10 Plants
32 Antioxidants |
|
| Description |
Natural compounds with free-radical scavenging
activity have potential role in maintaining human health and
preventing diseases. In this study, we report the antioxidant
and cytoprotective properties of 14-aminotetradecanoic acid
(ATDA) isolated from the Decalepis hamiltonii roots.
ATDA is a potent scavenger of superoxide (O2
•-), hydroxyl
(•OH), nitric oxide (•NO), and lipid peroxide (LOO•) physiologically
relevant free radicals with IC50 values in nM
(36–323) range. ATDA also exhibits concentration-dependent
secondary antioxidant activities like reducing power,
metal-chelating activity, and inhibition of protein carbonylation.
Further, ATDA at nM concentration prevented
CuSO4-induced human LDL oxidation. ATDA demonstrated
cytoprotective activity in primary hepatocytes and
Ehrlich ascites tumor cells against oxidative stress inducing
xenobiotics apart from the in vitro free-radical scavenging
activity. The mechanism of cytoprotective action involved
maintaining the intracellular glutathione, scavenging of
reactive oxygen species, and inhibition of lipid peroxidation.
It is suggested that ATDA is a novel bioactive molecule with
potential health implications.
|
|
| Date |
2012
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://ir.cftri.com/4436/1/Molecular%20and%20Cellular%20Biochemistry%2C%202012%2C%20Volume%20364%2C%20Numbers%201%2D2%2C%20Pages%201%2D9.pdf
Anup, Srivastava and Jagan Mohan Rao, L. and Shivanandappa, T. (2012) 14-Aminotetradecanoic acid exhibits antioxidant activity and ameliorates xenobiotics-induced cytotoxicity. Molecular and Cellular Biochemistry, 364 (1-2). pp. 1-9. ISSN 0300-8177 |
|
| Relation |
http://ir.cftri.com/4436/
|
|