Supplementation and delivery of n-3 fatty acids through spray-dried milk reduce serum and liver lipids in rats.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/2012/
Lipids-05-04 |
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| Title |
Supplementation and delivery of n-3 fatty acids through spray-dried milk reduce serum and liver lipids in rats.
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| Creator |
Ramaprasad, T. R.
Baskaran, V. Sambaiah, K. Lokesh, B. R. |
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| Subject |
17 Fatty Acid Chemistry
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| Description |
Indian diets comprising staples such as cereals, millets, and pulses provide 4.8 energy % from linoleic acid (18:2n-6) but fail to deliver adequate amounts of n-3 FA. Consumption of long-chain n-3 PUFA such as EPA (20:5n-3) and DHA (22:6n-3) is restricted to those who consume fish. The majority of the Indian population, however, are vegetarians needing additional dietary sources of n-3 PUFA. The present work was designed to use n-3 FA-enriched spray-dried milk powder to provide n-3 FA. Whole milk was supplemented with linseed oil to provide alpha-linolenic acid (LNA, 18:3n-3), with fish oil to provide EPA and DHA, or with groundnut oil (GNO), which is devoid of n-3 PUFA, and then spray-dried. Male Wistar rats were fed the spray-dried milk formulations for 60 d. The rats given formulations containing n-3 FA showed significant increases (P < 0.001) in the levels of LNA or EPA/DHA in the serum and in tissue lipids as compared with those fed the GNO control formulation. Rats fed formulations containing n-3 FA had 30-35% lower levels of serum total cholesterol and 25-30% lower levels of serum TAG than control animals. Total cholesterol and TAG in the livers of rats fed the formulations containing n-3 FA were lower by 18-30% and 11-18%, respectively, compared with control animals. This study showed that spray-dried milk formulations supplemented with n-3 FA are an effective means of improving dietary n-3 FA intake, which may decrease the risk factors associated with cardiovascular disease.
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| Date |
2004
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Article
PeerReviewed |
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application/pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/2012/1/Lipids_39%287%29_July_2004.pdf
Ramaprasad, T. R. and Baskaran, V. and Sambaiah, K. and Lokesh, B. R. (2004) Supplementation and delivery of n-3 fatty acids through spray-dried milk reduce serum and liver lipids in rats. Lipids, 39 (7). pp. 627-32. ISSN 0024-4201 |
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