Dietary n-3 but not n-6 fatty acids modulate anthropometry and fertility indices in high-fat diet fed rats: a two-generation study.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/14696/
https://doi.org/10.1007/s13197-020-04548-6 |
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| Title |
Dietary n-3 but not n-6 fatty acids modulate anthropometry
and fertility indices in high-fat diet fed rats: a two-generation
study.
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| Creator |
Breetha, R.
Mehrdad, Zarei Pooja, Acharya Ramaprasad, T. R. |
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| Subject |
11 Lipid Biochemistry
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| Description |
The present study assessed the modulatory
potentials of dietary n-3 [a-linolenic acid (ALA, 18:3n-3,
eicosapentaenoic acid (EPA, 20:5n-3 ? docosahexaenoic
acid (DHA) 22:6n-3), and n-6 fatty acid (LA, 18:2n-6)] on
anthropometric parameters and fertility indices in high-fatfed rats. Weanling female Wistar rats were fed with control
diet (7% lard), high-fat diet (35% lard, HFL), high-fat with
fish oil (21% fish oil ? 14% lard, HFF), high-fat with
canola oil (21% canola oil ? 14% lard, HFC) and high-fat
with sunflower oil (21% sunflower oil ? 14% lard, HFS)
for 2 months, mated and continued on their diets during
pregnancy. At gestation day 18–20, the intra-uterine environment was examined in representative rats, and the rest
were allowed for delivering pups. The pups after lactation
were subjected to mating and feeding trials as above.
Growth parameters (body weight, body length (BL),
abdominal circumference (AC), thoracic circumference
(TC), and Lee index and fertility parameters (litter size and
sex ratio) were studied. Feeding HFL diet increased BL
(16%), AC (33%) and TC (21%) compared to control
(p\0.05). Adipose tissue accumulation was 11% higher
in the HFL group compared to control and was lowered
with n-3 fatty acid incorporation in the diet. HFL group
exhibited a lower percentage of fertility, pregnancy, and
delivery indices. Litter size was decreased by 20%, and
litter weight was increased by 23% in HFL group compared to control with more male pups. Our study indicated
that n-3 to a larger extent than n-6 fatty acids modulated
high-fat induced changes in the anthropometric parameters
and fertility indices.
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| Date |
2021
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/14696/1/J%20Food%20Sci%20Technol%202020_4.pdf
Breetha, R. and Mehrdad, Zarei and Pooja, Acharya and Ramaprasad, T. R. (2021) Dietary n-3 but not n-6 fatty acids modulate anthropometry and fertility indices in high-fat diet fed rats: a two-generation study. Journal of Food Science and Technology, 58 (1). pp. 349-355. ISSN 0022-1155 |
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