A modified pectic polysaccharide from turmeric (Curcuma longa) with antiulcer effects via anti–secretary, mucoprotective and IL–10 mediated anti–inflammatory mechanisms.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
View Archive Info| Field | Value | |
| Relation |
http://ir.cftri.com/13829/
https://dx.doi.org/10.1016/j.ijbiomac.2018.06.053 |
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| Title |
A modified pectic polysaccharide from turmeric (Curcuma longa)
with antiulcer effects via anti–secretary, mucoprotective and
IL–10 mediated anti–inflammatory mechanisms.
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| Creator |
Rajagopal, H. M.
Srikanta, B. M. Chandraprakash, S. Shylaja, M. Dharmesh |
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| Subject |
28 Polysaccharide Chemistry
07 Turmeric |
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| Description |
Antiulcer potency of structurally defined low molecular weight modified pectin from turmeric
(MTrPP) including inhibitory effects on H. pylori has been demonstrated previously by us. Given
that ulcer is a disorder characterized by inflammatory responses leading to initiation, aggravation
and perpetuation of disease conditions, the present study aims to understand the possible anti–
inflammatory mechanisms through which MTrPP delivered antiulcer effects. Rats triggered with
early phase gastric inflammation (LPS) followed by ulcer induction (swim–stress) were
pretreated with MTrPP (150 mg/kg b.w) for 14 days. Inflammation and ulcer–specific markers
were screened to assess the protective effects. MTrPP offered up to 91% protection by limiting
the production of pro–inflammatory factors (TNF–α, IL–8, NF–кB) and by the tight differential
regulation of cyclooxygenase (COX–1, 2), mitogen–activated–protein–kinase (p–p38, p–ERK–
1/2) and matrix metalloproteinase (pro–MMP–9). MTrPP showed modulatory effects through
inhibition of galectin–3, oxidative stress, H+,K+–ATPase and elicitation of gastro–protective
mediators such as, mucin, prostaglandin E2, NOx, zinc, IgA etc. Results revealed that MTrPP
mediated the overall protection by creating an environment conducive to protection by switching
from the inflammatory to anti–inflammatory phase via IL–10 over expression.
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| Date |
2018
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/13829/1/International%20Journal%20of%20Biological%20Macromolecules%202018.pdf
Rajagopal, H. M. and Srikanta, B. M. and Chandraprakash, S. and Shylaja, M. Dharmesh (2018) A modified pectic polysaccharide from turmeric (Curcuma longa) with antiulcer effects via anti–secretary, mucoprotective and IL–10 mediated anti–inflammatory mechanisms. International Journal of Biological Macromolecules, 118. pp. 864-880. ISSN 0141-8130 |
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