Evidence of neuropeptide bivalency in the interaction of substance p with cerabroside sulphate.
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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http://ir.cftri.com/4160/
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| Title |
Evidence of neuropeptide bivalency in the interaction of substance p with cerabroside sulphate.
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| Creator |
Appu Rao, A. G.
Cann, J. R. Stewart, J. M. Winzor, D. J. |
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| Subject |
25 Peptide Chemistry
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| Description |
A precipitin effect has been observed with mixtures of cerebroside sulfate and the neuropeptide substance
P. This phenomenon is attributed to multivalency of the lipid due to its existence in micellar form, and to
bivalency of substance P. One of those neuropeptide sites is almost certainly the basic residue(s) located at
the N-terminal of substance P, whereas the hydrophobic residues at the C-terminus are suggested as
candidates for the other site on the basis of turbidimetric, circular dichroic, and fluorometric studies. An
intrinsic association constant of 3.6 x 10' M-' has been obtained from the cerebroside sulfate concentration
associated with maximal turbidity of mixtures containing a fixed concentration of the neuropeptide.
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| Date |
1990
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| Type |
Article
PeerReviewed |
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| Format |
pdf
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| Language |
en
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| Identifier |
http://ir.cftri.com/4160/1/Int.%20J.%20Peptide%20Protein%20Res.%2035%2C%201990.%20258-262.pdf
Appu Rao, A. G. and Cann, J. R. and Stewart, J. M. and Winzor, D. J. (1990) Evidence of neuropeptide bivalency in the interaction of substance p with cerabroside sulphate. International Journal of Peptide and Protein Research, 35 (3). pp. 250-262. |
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