A Short-Term Toxicity Study of Aspergillus Carbonarius Carotenoid
IR@CFTRI: CSIR-Central Food Technological Research Institute, Mysore
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| Relation |
http://ir.cftri.com/12299/
http://dx.doi.org/10.1177/1091581811430402 |
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| Title |
A Short-Term Toxicity Study of
Aspergillus Carbonarius Carotenoid
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| Creator |
Anbarasu, K.
Akshatha, H.S. Muthukumar, S. P. Umesh Kumar, S. |
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| Subject |
03 Fungi
17 Toxicology |
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| Description |
In a pharmacokinetic study, high-performance liquid chromatography analysis of blood samples of Wistar female rats fed with
partially saturated canthaxanthin (PSC) of Aspergillus carbonarius showed the presence of the carotenoid in the plasma within
6 hours of feeding. In another study for safety assessment of PSC fed to rats over a period of 28 days at 0.05%, 0.10%, and 0.25%,
the rats showed no changes in food intake. There were no significant differences observed in body weight, hematological
parameters, or serum clinical enzymes compared to the control group not fed with PSC. Deposition of PSC in the eyes of the
rats was also not observed. The results showed that PSC-fed rats were not adversely affected as far as toxicological studies were
concerned.
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| Date |
2012
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Language |
en
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| Rights |
—
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| Identifier |
http://ir.cftri.com/12299/1/International%20Journal%20of%20Toxicology%2031%282%29%20158-165.pdf
Anbarasu, K. and Akshatha, H.S. and Muthukumar, S. P. and Umesh Kumar, S. (2012) A Short-Term Toxicity Study of Aspergillus Carbonarius Carotenoid. International Journal of Toxicology, 31 (2). pp. 158-165. |
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