A Case for Pharmacogenomics in Management of Cardiac Arrhythmias
IR@IGIB: CSIR-Institute of Genomics & Integrative Biology, New Delhi
View Archive Info| Field | Value | |
| Title |
A Case for Pharmacogenomics in Management of Cardiac
Arrhythmias
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| Creator |
Kandoi, Gaurav
Nanda, Anjali Scaria, Vinod Sivasubbu, Sridhar |
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| Subject |
BI1 Bioinformatics (General)
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| Description |
Disorders of the cardiac rhythm are quite prevalent in clinical practice. Though the variability in drug response
between individuals has been extensively studied, this information has not been widely used in clinical practice.
Rapid advances in the field of pharmacogenomics have provided us with crucial insights on inter-individual genetic
variability and its impact on drug metabolism and action. Technologies for faster and cheaper genetic testing and
even personal genome sequencing would enable clinicians to optimize prescription based on the genetic makeup
of the individual, which would open up new avenues in the area of personalized medicine. We have systematically
looked at literature evidence on pharmacogenomics markers for anti-arrhythmic agents from the OpenPGx
consortium collection and reason the applicability of genetics in the management of arrhythmia. We also discuss
potential issues that need to be resolved before personalized pharmacogenomics becomes a reality in regular
clinical practice.
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| Date |
2012
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://openaccess.igib.res.in/141/1/Document1.pdf
Kandoi, Gaurav and Nanda, Anjali and Scaria, Vinod and Sivasubbu, Sridhar (2012) A Case for Pharmacogenomics in Management of Cardiac Arrhythmias. A Case for Pharmacogenomics in Management of Cardiac Arrhythmias , 2 (12). ISSN 0972-6292 |
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| Relation |
http://www.ipej.org/1202/vinod.htm
http://openaccess.igib.res.in/141/ |
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