One-Pot Multicomponent Michael and Thorpe-Ziegler Reaction of Aryl Methyl Ketones
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
View Archive Info| Field | Value | |
| Title |
One-Pot Multicomponent Michael and Thorpe-Ziegler Reaction of Aryl
Methyl Ketones
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| Creator |
Jaitak, V
---, Bandna Das, Pralay Kaul , V K Singh , Bikram Kumar, Neeraj |
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| Subject |
Plant sciences
Natural Product Chemistry |
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| Description |
Abstract A regioselective base-promoted Michael and Thorpe–Ziegler reaction between
aryl methyl ketones and a,b-unsaturated nitrile was carried out in a single step. Different
functional groups in addition to active positions were tolerated under this condition. Results
indicated that the reaction proceeds in a consecutive manner as double Michael, triple
Michael, and Thorpe–Ziegler condensation. By applying click chemistry, double Michael
adducts were converted to bis-tetrazoles, which have broad applications in coordination
and medicinal chemistry.
Supplemental materials are available for this article. Go to the publisher’s online edition
of Synthetic Communications1 to view the free supplemental file
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/966/1/Synthetic_communication.pdf
Jaitak, V and ---, Bandna and Das, Pralay and Kaul , V K and Singh , Bikram and Kumar, Neeraj (2011) One-Pot Multicomponent Michael and Thorpe-Ziegler Reaction of Aryl Methyl Ketones. Journal of Synthetic Communications, 41. pp. 2727-2737. |
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| Relation |
http://ihbt.csircentral.net/966/
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