Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
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| Title |
Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential
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| Creator |
Yousuf, Syed Khalid
Majeed, Rabiya Ahmad, Mudassier Sangwan, Payare lal Purnima, Basant Saxsena, A.K. Suri, K.A. Mukherjee, Debaraj Taneja, Subhash Chandra |
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| Subject |
Chemical Sciences
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| Description |
Regio-/stereoselective Michael addition to ring A of withaferin-A was performed using an optimized reaction procedure to synthesise a library of 2,3-dihydro,3-�-substituted withaferin-A derivatives. The analogues thus obtained were evaluated for in vitro cytotoxicity against various human cancer cell lines.3-Azido analogue exhibited 35-fold increase (IC50 = 0.02–1.9 �M) in cytotoxicity against almost the entire cell lines tested when compared to the parent molecule. However, further modifications of 3-azido analogue with various alkynes under Husigen’s cycloaddition conditions generated a variety of triazole
derivatives with reduced cytotoxicity.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/333/1/10.1016j.steroids.2011.05.012.pdf
Yousuf, Syed Khalid and Majeed, Rabiya and Ahmad, Mudassier and Sangwan, Payare lal and Purnima, Basant and Saxsena, A.K. and Suri, K.A. and Mukherjee, Debaraj and Taneja, Subhash Chandra (2011) Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential. Steroids, 76 (10-11). pp. 1213-1222. ISSN 0039128X |
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| Relation |
http://dx.doi.org/10.1016/j.steroids.2011.05.012
http://iiim.csircentral.net/333/ |
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