Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus
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| Creator |
Mirza, Z. M.
Kumar, A. Kalia, N. P. Zargar, A. Khan, I. A. |
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| Subject |
Pharmacological Sciences
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| Description |
Piperine, a trans-trans-isomer of 1-piperoyl-piperidine, was tested in combination with mupirocin for antimicrobial activity against Staphylococcus aureus strains including meticillin-resistant S. aureus. The combination markedly reduced the MIC of mupirocin and also lowered the
mutation frequency. Enhanced accumulation and efflux of ethidium bromide from wild-type and mutant (Mupr-1) strains in the presence of piperine indicated that inhibition of efflux could be a possible mechanism of potentiation of mupirocin activity by piperine. The combination of piperine ; with mupirocin in a dermal infection model of mice showed better in vivo efficacy when compared with the commercially available formulation of 2% mupirocin.
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| Date |
2011
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/311/2/10.1099jmm.0.033167%2D0.pdf
Mirza, Z. M. and Kumar, A. and Kalia, N. P. and Zargar, A. and Khan, I. A. (2011) Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus. Journal of Medical Microbiology, 60 (10). pp. 1472-1478. ISSN 0022-2615 |
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| Relation |
http://dx.doi.org/10.1099/jmm.0.033167-0
http://iiim.csircentral.net/311/ |
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