Search for new pharmacophores for antimalarial activity (Part III): Synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive InfoField | Value | |
Creator |
Mishra, A
Srivastava, K Tripathi, R Puri, S K Batra, Sanjay |
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Date |
2010-03-02T06:27:37Z
2010-03-02T06:27:37Z 2009 |
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Identifier |
European Journal of Medicinal Chemistry (2009), 44 (11), 4404-4412
http://hdl.handle.net/123456789/520 |
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Description |
Syntheses and in vitro antimalarial evaluation of 42 new thioureido quinazolines have been carried out. Several analogs showed promising antimalarial effect in the in vitro investigation against chloroquine-sensitive 3D7 strain of P. falciparum whereas one of the compounds shows 50% curative effect in the mouse model at an oral dose of 100mg/kg x 4 days against multi drug resistant P. yoelii nigeriensis
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Format |
144420 bytes
application/pdf |
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Language |
en
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Relation |
CDRI Communication Number 7714
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Subject |
antimalarial
thioureido quinazolines chloroquine P. falciparum P. yoelii nigeriensis |
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Title |
Search for new pharmacophores for antimalarial activity (Part III): Synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines
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Type |
Article
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