Synthesis and antitubercular screening of imidazole derivatives
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Pandey, Jyoti
Tiwari, Vinod K Verma, Shyam S Chaturvedi, Vinita Bhatnagar, Shalini Sinha, Sudhir Gaikwad, A N Tripathi, R P |
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| Date |
2009-08-31T11:33:41Z
2009-08-31T11:33:41Z 2009 |
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| Identifier |
European Journal of Medicinal Chemistry(2009),44, 3350–3355
http://hdl.handle.net/123456789/488 |
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| Description |
A series of imidazole based compounds were synthesized by reacting simple imidazoles either with alkyl halides in presence of tetrabutylammonium bromide (TBAB) or by conjugate addition of imidazoles to ethyl acrylate or glycosyl olefinic ester. The synthesized compounds were screened against M. tuberculosis where compound 17 exhibited good in vitro antitubercular activity that may serve as a lead for further optimization.
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| Format |
160798 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 7398
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| Subject |
Tuberculosis
Imidazoles Glycosyl amino ester C-allylation |
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| Title |
Synthesis and antitubercular screening of imidazole derivatives
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| Type |
Article
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