A facile synthesis of α, α´-(EE)-bis(benzylidene)-cycloalkanones and their antitubercular evaluations
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Singh, Nimisha
Pandey, Jyoti Yadav, Amit Chaturvedi, Vinita Bhatnagar, Shalini Gaikwad, Anil N Sinha, Sudhir Kumar Kumar, Awaneet Shukla, P K Tripathi, R P |
|
| Date |
2009-08-31T06:31:58Z
2009-08-31T06:31:58Z 2009 |
|
| Identifier |
European Journal of Medicinal Chemistry(2009), 44, 1705–1709
http://hdl.handle.net/123456789/481 |
|
| Description |
An economical and facile synthesis of α, α′-(EE)-bis(benzylidene)-cycloalkanones was achieved by reaction of cycloalkanones with different aromatic aldehydes using ethanolic KOH in good yields. Few of the selected compounds were reduced with NaBH4 to the respective α, α′-(EE)-bis(benzylidene)-cycloalkanols. All these compounds and our earlier synthesized cyclohexyl phenyl methanols were evaluated for their antitubercular, antifungal and antibacterial activities. Several compounds displayed moderate antitubercular activity with MIC 12.5-1.56 μg/mL. However, none of the compounds displayed any significant antifungal activity.
|
|
| Format |
194820 bytes
application/pdf |
|
| Language |
en
|
|
| Relation |
CDRI Communication No. 7369
|
|
| Subject |
α, α′-(EE)-bis(benzylidene)-cycloalkanones
Antifungal Antitubercular |
|
| Title |
A facile synthesis of α, α´-(EE)-bis(benzylidene)-cycloalkanones and their antitubercular evaluations
|
|
| Type |
Article
|
|