Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Dixit, Manish
Saeed, Uzma Kumar, Amit Siddiqi, M I Tamrakar, A K Srivastava, A K Goel, Atul |
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| Date |
2009-08-18T10:07:01Z
2009-08-18T10:07:01Z 2008 |
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| Identifier |
Med. Chem.(2008), 4, 18-24
http://hdl.handle.net/123456789/480 |
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| Description |
Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that plays a critical role in down-regulating insulin signaling through dephosphorylation of the insulin receptor. Inhibitors of PTP1B showed increased insulin sensitivity and normalize plasma glucose level and thus are useful therapeutic agents for the treatment of diabetes. A series of functionalized 4,5-dihydronaphthofurans and dibenzofurans were synthesized, studied through molecular docking and evaluated for their PTP1B inhibitory activity.
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| Format |
2488585 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 7051
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| Subject |
Diabetes
PTP1B 4,5-dihydronaphthofuran dibenzofuran molecular docking |
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| Title |
Synthesis, Molecular Docking and PTP1B Inhibitory Activity of Functionalized 4,5-Dihydronaphthofurans and Dibenzofurans
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| Type |
Article
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