Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Tripathi, R P
Saxena, Nisha Tiwari, V K Verma, S S Chaturvedi, Vinita Manju, Y K Srivastva, A K Gaikwad, A Sinha, S |
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| Date |
2009-02-10T19:22:02Z
2009-02-10T19:22:02Z 2006 |
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| Identifier |
Biorganic & Med.Chem.14,8186 (2006)
http://hdl.handle.net/123456789/323 |
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| Description |
A total of 42 benzyl-and pyridylmethyl amines were synthesized either by reductive amination of aromatic/heteroaromatic aldehydes with amines or by conjugate addition of amines to the cinnamates followed by reduction of the ester group with lithium aluminium hydride to the respective propanolamines. All the synthesized compounds were evaluated against both avirulent and virulent strains of M. tuberculosis. Many of the compounds exhibited MIC as low as 1.56 μg/ml. Few of potent compounds were also evaluated against clinical isolates of MDR TB and found to be active at one or other concentrations with MIC as low as 3.12μg /ml.
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| Format |
229293 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No 7035
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| Subject |
Tuberculosis
MDR TB Phenylmethyl amines Antitubercular agents Reductive amination |
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| Title |
Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines
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| Type |
Article
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