Reductive amination of glycoyl aldoses: synthesis of n-glycosylated beta-glycosyl amino alcohols and their antidiabetic potential
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Verma, S S
Mishra, R C Tamrakar, A K Tripathi, B K Srivastava, A K Tripathi, R P |
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| Date |
2009-02-10T19:22:02Z
2009-02-10T19:22:02Z 2004 |
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| Identifier |
J. Carbohydr. Chem. 23, 493.( 2004)
http://hdl.handle.net/123456789/316 |
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| Description |
Reductive amination of glycosyl aldehydes (1a-1c, 2) with glycosyl amino esters (3a-3c, 4) in presence of sodium borohydride gave diglycosylated amino esters (5-15) in good yields. N-Glycosyl-glycosylated amino esters were reduced to the respective diglycosyl amino alcohols (16-26) with LiAlH4 in good yierlds. All the synthesized compounds were studied for their inhibitory effect, if any, against hepatic glucose-6-phosphatase, glycogen phosphorylase and intestinal brush border membrane -glucosidase, among these compounds 7, 21 and 25 have shown marked inhibition on these enzymes, respectively.
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248423 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 6605
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| Title |
Reductive amination of glycoyl aldoses: synthesis of n-glycosylated beta-glycosyl amino alcohols and their antidiabetic potential
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| Type |
Article
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