Diastereoselective synthesis of glycosylated prolines as α-glucosidase inhibitors and organocatalyst in asymmetric aldol reaction
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Pandey, Jyoti
Dwivedi, Namrata Srivastava, A K Tamarkar, A Tripathi, R P |
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| Date |
2009-02-10T19:21:46Z
2009-02-10T19:21:46Z 2007 |
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| Identifier |
Bioorganic & Med. Chem. Letters 17, 1321 (2007)
http://hdl.handle.net/123456789/308 |
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| Description |
1,3-Dipolar cycloaddition of azomethine ylides and glycosyl E-olefins in presence of LDA led to diastereoselective formation of C-glycosylated proline esters. The selected esters on regioselective hydrolysis with LiOH gave C-glycosyl prolines. Few of the proline esters exhibited very good α-glucosidase inhibitory activity. The organocatalytic activity of one of the prolines in a prototype Aldol reaction has also been established.
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| Format |
166390 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No 7057
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| Title |
Diastereoselective synthesis of glycosylated prolines as α-glucosidase inhibitors and organocatalyst in asymmetric aldol reaction
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| Type |
Article
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