An Efficient Synthesis of Aryloxyphenyl Cyclopropyl Methanone: A New Class of Antimycobacterial Agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Dwivedi, Namrata
Tewari, Neetu Tiwari, V K Chaturvedi, Vinita Manju, Y K Srivastava, A Giakwad, A Sinha, S Tripathi, R P |
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| Date |
2009-01-08
2009-01-08 2005 |
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| Identifier |
Bioorg Med Chem Lett.15, 4526-30 (2005)
http://hdl.handle.net/123456789/277 |
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| Description |
An efficient, high yield and one pot synthesis of phenyl cyclopropyl methanones on reaction of different aryl alcohols with 4’-fluoro-4-chloro-butyrophenone in THF/DMF in presence of NaH /TBAB is reported. All the compounds were evaluated for their antitubercular activities against M. tuberculosis H37 Rv in vitro displaying MICs ranging from 25-3.125 mcg/ml. The most active compounds showed activity against MDR strains and one of them showed marginal enhancement MST in mice.
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| Format |
142409 bytes
application/pdf |
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| Language |
en
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| Subject |
Tuberculosis
Tetrabutylammonium bromide Phenyl cyclopropyl methanones Wolf- Kishner reduction |
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| Title |
An Efficient Synthesis of Aryloxyphenyl Cyclopropyl Methanone: A New Class of Antimycobacterial Agents
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| Type |
Article
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