An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Singh, Biswajit K
Bisht, Surendra Singh Tripathi, R P |
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| Date |
2009-01-08
2009-01-08 2006 |
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| Identifier |
Beilstein J. Org. Chem.- Art No. 24 (2006)
http://hdl.handle.net/123456789/275 |
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| Description |
A straightforward synthesis of tetramic acid derivatives with dienyl susbstituents at C-5 from L-ascorbic acid is reported. The synthesis involves the PCC oxidation of allylic alcohol followed by olefination and subsequent reaction with different amines to give 5-hydroxy lactams, which underwent pTSA catalysed dehydration to give the required tetramic acid derivatives.
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| Format |
194939 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No.7040
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| Subject |
Ascorbic acid
DBU Tetramic acid Wittig Reaction Pyridinium chlorochromate |
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| Title |
An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid
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| Type |
Article
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