Asymmetric Distribution of Phosphatidylethanolamine in C. albicans: Possible Mediation by CDRI, a Multidrug Transporter Belonging to ATP Binding Cassette (ABC) Superfamily
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Dogra, S
Krishnamurthy, S Gupta, V Dixit, B L Gupta, C M Sanglard, D Prasad, R |
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| Date |
2008-12-22T13:56:08Z
2008-12-22T13:56:08Z 1999 |
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| Identifier |
Yeast 15,111-121 (1999)
http://hdl.handle.net/123456789/242 |
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| Description |
By using two molecular probes, we demonstrate that only 4% of total phosphatidylethanolamine (PtdEtn) in the plasma membrane (PM) of a human pathogenic yeast, Candida albicans, is present in its external half. Evidence is presented to show that the availability of PtdEtn could be related to the expression of a multidrug transporter CDRI of C. albicans, and the process is energy-dependent. A homozygous CDRI disruptant strain of C. albicans shows almost 23% reduction in the external labelling of PtdEtn. This report shows that, similar to human MDRs, yeast multidrug transporter could also be involved in aminophospholipid translocation.
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| Format |
4238905 bytes
application/pdf |
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| Language |
en
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| Subject |
membrane asymmetry
multidrug resistance aminophospholipid translocation ABC transporter C. albicans |
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| Title |
Asymmetric Distribution of Phosphatidylethanolamine in C. albicans: Possible Mediation by CDRI, a Multidrug Transporter Belonging to ATP Binding Cassette (ABC) Superfamily
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| Type |
Article
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