Immunomodulator Tuftsin Augments Antifilarial Activity of Diethylcarbamazine Against Experimental Brugian Filariasis
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Owais, M
Bhattacharya-Misra, Shailja Haq, W Gupta, C M |
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| Date |
2008-10-03T15:36:19Z
2008-10-03T15:36:19Z 2003 |
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| Identifier |
J.of Drug Targeting.11,247-251 (2003)
http://hdl.handle.net/123456789/203 |
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| Description |
In the present study, we evaluated the potential of an immunomodulator tuftsin in increasing the efficacy of liposomised diethylcarbamazine (DEC) against experimental filarial infection of Brugia malayi. The liposomised form of DEC, when used at sub-optimal dose of 25 mglkg body weight,successfully eliminated filarial parasite from systemic circulation in animals inflicted with B. malayi infection. However, the formulation was effective upto 60 days post infection only, followed by recurrence of the infection. In contrast, the co-administration of liposomal formulation of DEC along with an immunomodulator tuftsin was found to be competent enough to suppress microfilarial stage of parasite till 90 days post treatment. Interestingly, tuftsin bearing DEC liposomes were found to be effective against adult parasite as well.
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| Format |
2866529 bytes
application/pdf |
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| Language |
en
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| Subject |
Antifilarial efficacy
Brugia malayi Diethylcarbamazine Filaria Liposome Tuftsin |
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| Title |
Immunomodulator Tuftsin Augments Antifilarial Activity of Diethylcarbamazine Against Experimental Brugian Filariasis
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| Type |
Article
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