A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Batra, Sanjay
Srivastava, Pratima Roy, Kamal Pandey, V C Bhaduri, A P |
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| Date |
2008-01-17T11:15:03Z
2008-01-17T11:15:03Z 2000 |
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| Identifier |
J. Med. Chem., 43, 3428-3433
http://hdl.handle.net/123456789/79 |
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| Description |
1-[(3’-Diethylaminopropyl)-3-(substitutedphenylmethylene) pyrrolidines] were synthe-sized and evaluated for CQ resistant reversal activity. The compounds of the series elicit better biological response than their phenyl methyl analogues in general. The most active compound 4b has been evaluated in vivo in details and the results are presented. The possible mode of action of the compounds of this series is by inhibition of the enzyme heme oxygenase, thereby increasing the levels of heme and hemozoin, which are lethal to the parasite.
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135174 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 6024
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| Title |
A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines
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Article
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