Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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| Creator |
Batra, Sanjay
Srinivasan, T Rastogi, S K Kundu, Bijoy Patra, A Bhaduri, A P Dikshit, Madhu |
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| Date |
2008-01-17T11:16:20Z
2008-01-17T11:16:20Z 2002 |
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| Identifier |
Bioorg. Med. Chem. Lett. 12, 1905-1908, Bioorganic & Medicinal Chemistry Letters 12 (2002) 3349
http://hdl.handle.net/123456789/80 |
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| Description |
The 3-substitutedphenyl-5-isoxazolecarboxaldehydes have been identified as activated aldehydes for the generation of isoxazole-based combinatorial libraries on solid phase through automation. Three highly functionalized isoxazole-based libraries comprising of 32, 96 and 45 compounds each have been synthesized in parallel format using Baylis Hillman reaction, Michael addition, reductive amination and alkylation reactions. With an objective of lead generation all the three libraries were evaluated for their antithrombin activity in vivo.
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122786 bytes
53757 bytes application/pdf application/pdf |
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| Language |
en
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| Relation |
CDRI Communication no. 6071
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| Title |
Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents
Corrigendum to ‘‘Combinatorial Synthesis and Biological Evaluation of Isoxazole-Based Libraries as Antithrombotic Agents’’ [Bioorg. Med. Chem. Lett. 12 (2002) 1905] |
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Article
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