A Facile synthesis of 3-Methylene-4-aryl-1,3,4,5-tetrahydro-benzo[b][1,4] di-azepin-2-ones and 3-arylemethylene-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-ylamines
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
View Archive Info| Field | Value | |
| Creator |
Pathak, Richa
Nag, Somnath Batra, Sanjay |
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| Date |
2007-12-29T08:16:48Z
2007-12-29T08:16:48Z 2006 |
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| Identifier |
Synthesis (2006), 4205-4211
http://hdl.handle.net/123456789/71 |
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| Description |
A simple and convenient synthesis of 3-methylene-4-aryl-1,3,4,5-tetrahydro-benzo[b][1,4] diazepin-2-ones was accomplished by the SN2 nucleophilic substitution of the acetates of Baylis-Hillman adducts of acrylate with 1,2-phenylenediamines followed by base-mediated intramolecular cyclization. On the other hand similar substrates derived from the Baylis-Hillman adducts of acrylonitrile via Pinner’s reaction leads to 3-arylmethylene-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-ylamines in good yields..
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148400 bytes
application/pdf |
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| Language |
en
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| Relation |
CDRI Communication No. 7050.
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| Subject |
Baylis-Hillman
1,2-phenylenediamine 3-Methylene-4-aryl-1 3,4,5-tetrahydro-benzo[b][1,4] diazepin-2-ones 3-arylmethylene-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-ylamines. |
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| Title |
A Facile synthesis of 3-Methylene-4-aryl-1,3,4,5-tetrahydro-benzo[b][1,4] di-azepin-2-ones and 3-arylemethylene-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-ylamines
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| Type |
Article
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