Hepatoprotective activity of indigtone-a bioactive fraction fromIndigofera tinctoria Linn.
IR@IIIM: CSIR-Indian Institute of Integrative Medicine, Jammu
View Archive Info| Field | Value | |
| Title |
Hepatoprotective activity of indigtone-a bioactive fraction fromIndigofera tinctoria Linn.
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| Creator |
Singh, B.
Saxena, A. K. Chandan, B. K. Bhardwaj, V. Gupta, V. N. Suri, O. P. Handa, S. S. |
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| Subject |
Chemical Sciences
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| Description |
A bioactive fraction, indigtone (FA), obtained by fractionation of a petroleum ether extract of the aerial
parts of Indigofera tinctoria, showed significant dose related hepatoprotective activity against CCl4
induced liver injury in rats and mice. Hexobarbitone induced ‘sleeptime’, zoxazolamine induced ‘paralysis
time’, levels of transaminases, bilirubin and total protein in serum were employed as indices of liver
injury. Pre and post treatment with FA significantly reversed the majority of the parameters altered by
the hepatotoxin. This indicated the preventive and restorative effect of FA in the process of CCl4 induced
liver damage. The fraction possessed a high therapeutic ratio, as no mortality was observed up to a dose
of 2g/kg p.o. in mice
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| Date |
2001
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://iiim.csircentral.net/176/1/10.1002ptr.760.pdf
Singh, B. and Saxena, A. K. and Chandan, B. K. and Bhardwaj, V. and Gupta, V. N. and Suri, O. P. and Handa, S. S. (2001) Hepatoprotective activity of indigtone-a bioactive fraction fromIndigofera tinctoria Linn. Phytotherapy Research, 15 (4). pp. 294-297. ISSN 0951-418X |
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| Relation |
http://dx.doi.org/10.1002/ptr.760
http://iiim.csircentral.net/176/ |
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