Larvicidal and Structure–Activity Studies of Natural Phenylpropanoids and Their Semisynthetic Derivatives against the Tobacco Armyworm Spodoptera litura (Fab.) (Lepidoptera: Noctuidae)1)
IR@IHBT: CSIR-Institute of Himalayan Bioresource Technology, Palampur
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| Title |
Larvicidal and Structure–Activity Studies of Natural Phenylpropanoids and
Their Semisynthetic Derivatives against the Tobacco Armyworm Spodoptera
litura (Fab.) (Lepidoptera: Noctuidae)1)
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| Creator |
Bhardwaj , A
Tewary, D K Kumar, R Kumar, V Sinha, Arun K |
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| Subject |
Pest and Pesticides
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| Description |
The larvicidal activity of 18 phenylpropanoids, 1–18, including phenylpropenoate, phenylpropenal,
phenylpropene, and their semisynthetic analogues, were evaluated against the tobacco armyworm,
Spodoptera litura (Fab.), to identify promising structures with insecticidal activity. Amongst various
phenylpropanoids, isosafrole, a phenylpropene, showed the best activity, with an LC50 value of 0.6 mg/leaf
cm2, followed by its hydrogenated derivative dihydrosafrole (LC50¼2.7 mg/leaf cm2). The overall
larvicidal activity of various phenylpropene derivatives was observed in the following order: isosafrole
(6)>dihydrosafrole (16)>safrole (12)>anethole (4)>methyl eugenol (11)>eugenol (13)>b-asarone
(8)>dihydroasarone (18)>dihydroanethole (15). Dihydrosafrole might be a promising compound,
although presenting a lower larvicidal activity than isosafrole, because of its better stability and resistance
to oxidative degradation (due to the removal of the extremely reactive olefinic bond) in comparison to
isosafrole. Such structure–activity relationship studies promote the identification of lead structures from
natural sources for the development of larvicidal products against S. litura and related insect pests.
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| Date |
2010
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://ihbt.csircentral.net/322/1/402_2010_Larvicidal.pdf
Bhardwaj , A and Tewary, D K and Kumar, R and Kumar, V and Sinha, Arun K (2010) Larvicidal and Structure–Activity Studies of Natural Phenylpropanoids and Their Semisynthetic Derivatives against the Tobacco Armyworm Spodoptera litura (Fab.) (Lepidoptera: Noctuidae)1). Chemistry and biodiversity, 7 (1). pp. 168-177. |
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| Relation |
http://ihbt.csircentral.net/322/
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