Chemomodulatory potential of <i style="">Glycine max </i>against murine skin and cervical papillomagenesis
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Singh, M
Mendez, E Rao, A Ramesha Kale, R K |
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| Date |
2011-11-01T05:00:26Z
2011-11-01T05:00:26Z 2011-11 |
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| Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://hdl.handle.net/123456789/13004 |
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| Description |
864-870
In the present study, chemopreventive potential of <i style="">Glycine max (G. Max) </i>seeds was examined against DMBA-induced skin and MCA-induced cervical papillomagenesis in Swiss albino mice. Different doses (2.5, 5, and 7.5% w/w) of <i style="">G. max</i> were provided to animals in feed. Results exhibited a significant reduction in skin as well as cervical tumor incidence and tumor multiplicity (up to 75%) at all doses of test diet as compared to the control. Relatively, 7.5% test diet was most effective in protecting the animals against carcinogenesis. Further, detoxifying enzymes and antioxidative status was also evaluated in the liver of mice to understand the role of <i style="">G. max</i> in prevention of cancer. It was observed that the test diet containing <i style="">G. max</i> significantly elevated the specific activities of glutathione-S-transferase (GST), DT-diaphorase (DTD), superoxide dismutase (SOD), catalase (CAT), and glyoxalase I (Gly I). The test diet also elevated the content of reduced glutathione whereas it decreased the level of the peroxidative damage along with the specific activity of lactate dehydrogenase. It appeared that <i style="">G. max</i> seeds provided chemoprevention against skin and cervical papillomagenesis probably by modulating the detoxifying and antioxidative enzymes. It could be inferred that intake of <i style="">G. max</i> might help in reducing the risk of cancer. |
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| Language |
en_US
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| Publisher |
NISCAIR-CSIR, India
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Source |
IJEB Vol.49(11) [November 2011]
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| Subject |
Biotransformation enzyme system
Chemoprevention G<i style="">lycine max</i> Papillomagenesis |
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| Title |
Chemomodulatory potential of <i style="">Glycine max </i>against murine skin and cervical papillomagenesis
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| Type |
Article
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