Chemoprotective influence of <i style="">Zanthoxylum</i> sps. on hepatic carcinogen metabolizing and antioxidant enzymes and skin papillomagenesis in murine model
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Rajamani, Paulraj
Banerjee, Sanjeev Rao, A Ramesha |
|
| Date |
2011-11-01T05:00:05Z
2011-11-01T05:00:05Z 2011-11 |
|
| Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://hdl.handle.net/123456789/13003 |
|
| Description |
857-863
In the present study, the putative potential of pericarp of dried fruit of <i style="">Zanthoxylum</i> (Rutaceae Family), a common spice additive in India’s west coast cuisines, in protecting against carcinogenesis has been reported. Extract from dried fruit of <i style="">Zanthoxylum</i> was orally administered to mice at two dose levels: 100 and 200 mg/kg body wt. for 14 days. Results reveal bifunctional nature of <i style="">Zanthoxylum</i> species as deduced from its potential to induce phase-I and phase-II enzyme activities associated with carcinogen activation and detoxification in the liver of mice. Hepatic glutathione S-transferase and DT-diaphorase were found significantly elevated by the treatment. <i style="">Zanthoxylum</i> was also effective in augmenting the antioxidant enzyme activities of glutathione peroxidase, superoxide dismutase and catalase albeit significantly by high dose of the extract (<i style="">P</i><0.05; <i style="">P</i><0.01). Reduced glutathione was also significantly elevated in the liver of treated animals (<i style="">P</i><0.05). The present study also investigated peri-initiation application of acetone extract of <i style="">Zanthoxylum</i> on initiated mouse skin. Results showed a significant reduction in tumor incidence from 68% to 36% (<i style="">P</i><0.05); as well as, a reduction in tumor burden per effective mouse from 3.87 to 0.72 (<i style="">P</i><0.01). Cumulatively, the findings strongly suggest cancer chemo-preventive potential of <i style="">Zanthoxylum</i> sps. |
|
| Language |
en_US
|
|
| Publisher |
NISCAIR-CSIR, India
|
|
| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
|
|
| Source |
IJEB Vol.49(11) [November 2011]
|
|
| Subject |
Antioxidant enzymes
Chemoprevention Xenobiotic detoxification <i style="">Zanthoxylum </i>sps |
|
| Title |
Chemoprotective influence of <i style="">Zanthoxylum</i> sps. on hepatic carcinogen metabolizing and antioxidant enzymes and skin papillomagenesis in murine model
|
|
| Type |
Article
|
|