Antioxidant properties of hydroxytyrosyl acetate compared with hydroxytyrosol and their protective capacity against oxidative stress in human neuroblastoma cells
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Ammendola, Sergio
Giusti, Anna M Masci, Alessandra Mosca, Luciana Saso, Luciano Bovicelli, Paolo |
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| Date |
2011-10-31T10:13:41Z
2011-10-31T10:13:41Z 2011-11 |
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| Identifier |
0975-1084 (Online); 0022-4456 (Print)
http://hdl.handle.net/123456789/12963 |
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| Description |
929-937
This study analyses antioxidant activity of synthetic hydroxytyrosol (HTy) and hydroxytyrosyl acetate (HTy-ac) against different reactive species. Both phenols were found to be able to scavenge superoxide anion as well as hydroxyl radical with comparable efficacy (40% and 80% scavenging activity, respectively). HTy-ac was found to be more effective than HTy or a-tocopherol as hydrogen peroxide scavenger (53%, 29% and 25% scavenging activity, respectively) (p£0.05). Human neuroblastoma cell line SH-SY5Y was chosen as an <i>ex vivo </i>model and cellular oxidative stress was assessed through the measurement of total free sulfhydryl groups and protein carbonyls. HTy displayed a high antioxidant ability against thiols oxidation at 10 <img src='/image/spc_char/micro.gif' border=0> M, whereas HTy-ac showed a great capacity in preventing carbonyl groups generation. Different antioxidant ability showed by tested compounds against oxidative stress in biological system can be attributed to molecular concentration, reducing power and lipophilicity. |
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| Language |
en_US
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| Publisher |
NISCAIR-CSIR, India
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Source |
JSIR Vol.70(11) [November 2011]
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| Subject |
Antioxidants
Hydroxytyrosol (HTy) Hydroxytyrosyl acetate (HTy-ac) Neuroblastoma cell line Olive oil Oxidative stress |
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| Title |
Antioxidant properties of hydroxytyrosyl acetate compared with hydroxytyrosol and their protective capacity against oxidative stress in human neuroblastoma cells
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| Type |
Article
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