Molecular mechanism of insulin resistance
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Molecular mechanism of insulin resistance
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| Creator |
Bhattacharya, S
Dey, D Roy, SS |
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| Subject |
Biology
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| Description |
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby causing insulin resistance and type 2 diabetes. However, the underlying mechanism involved is still unclear. In searching for the cause of the mechanism, it has been found that palmitate inhibits insulin receptor (IR) gene expression, leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKC epsilon causes this reduction in insulin receptor gene expression. One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies. We provide an overview of this important area, emphasizing the current status.
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| Publisher |
INDIAN ACADEMY SCIENCESBANGALOREC V RAMAN AVENUE, SADASHIVANAGAR, P B #8005, BANGALORE 560 080, INDIA
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| Date |
2011-09-20T12:12:39Z
2011-09-20T12:12:39Z 2007 |
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| Type |
Review
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| Identifier |
JOURNAL OF BIOSCIENCES
0250-5991 http://hdl.handle.net/123456789/14361 |
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| Language |
English
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