Synchronous modulation of cell surface lectin and its receptor in a homologous cell population: A novel mechanism of cellular regulation
Metadata of CSIR Papers
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| Title |
Synchronous modulation of cell surface lectin and its receptor in a homologous cell population: A novel mechanism of cellular regulation
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| Creator |
Banerjee, S
Dunydung, SR Das, K Majumder, GC |
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| Subject |
Oncology; Cell Biology
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| Description |
Testicular immotile sperm undergo maturation during epididymal transit when these cells pass through caput, corpus, and cauda-epididymal regions. Maturing goat spermatozoa specifically at the distal corpus epididymal stage show head-to-head auto agglutination when incubated in vitro in a modified Ringer's solution. Here, we show the biochemical mechanism of auto agglutination event and its functional significance. A lectin-like molecule located on sperm surface specifically interacts with its receptor of the neighboring homologous cells to cause autoagglutination. Lectin is a Ca++-dependent galactose-specific protein. Failure of the pre- and post-distal corpus sperm to show autoagglutination is due to lack of lectin-like molecule and its receptors, respectively. Maturing sperm at distal corpus stage acquire lectin-like molecule followed by sharp disappearance of its receptor, and this event is synchronously associated with the initiation of sperm forward motility that is essential for fertilization in vivo. Lectin and its receptor isolated from sperm plasma membrane showed high efficacy for blocking auto agglutination phenomenon. The data are consistent with the view that synchronous modulation of homologous cell surface lectin and their receptors constitutes a novel mechanism for cellular regulation by generating waves of signals by manipulating lectin-sugar-dependent "self-talk" and cell-cell "cross-talk". (c) 2006 Elsevier Inc. All rights reserved.
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| Publisher |
ELSEVIER INCSAN DIEGO525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
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| Date |
2011-09-20T12:12:11Z
2011-09-20T12:12:11Z 2006 |
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| Type |
Article
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| Identifier |
EXPERIMENTAL CELL RESEARCH
0014-4827 http://hdl.handle.net/123456789/14161 |
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| Language |
English
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