Inhibition of benzo[a]pyrene induced mutagenicity and genotoxicity by black tea polyphenols theaflavins and thearubigins in multiple test systems
Metadata of CSIR Papers
View Archive Info| Field | Value | |
| Title |
Inhibition of benzo[a]pyrene induced mutagenicity and genotoxicity by black tea polyphenols theaflavins and thearubigins in multiple test systems
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| Creator |
Halder, B
Pramanick, S Mukhopadhyay, S Giri, AK |
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| Subject |
Food Science & Technology; Toxicology
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| Description |
This study investigated the antimutagenic and anticlastogenic effects of black tea polyphenols, theaflavins (TF) and thearubigins (TR) in Salmonella assay in vitro and in vivo in bone marrow cells of mice as measured by chromosomal aberrations (CA) and sister chromatid exchange (SCE) against a known carcinogen, benzo[a]pyrene (B[a]P). A significant decrease in mutagenicity in Salmonella assay and both CA and SCE were observed in all the different concentrations of TF and TR plus B[a]P treated series when compared with B[a]P treated group alone. These results indicate that both TF and TR have significant antimutagenic and anticlastogenic effects. (C) 2005 Elsevier Ltd. All rights reserved.
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| Publisher |
PERGAMON-ELSEVIER SCIENCE LTDOXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
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| Date |
2011-09-20T12:11:58Z
2011-09-20T12:11:58Z 2005 |
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| Type |
Article
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| Identifier |
FOOD AND CHEMICAL TOXICOLOGY
0278-6915 http://hdl.handle.net/123456789/14066 |
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| Language |
English
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