7-[(4-Substituted phenyl-piperazin-1-yl)-alkoxyl]-4-methylchromene-2-ones as potential atypical antipsychotics: Synthesis and pharmacological evaluation
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Creator |
Shelke, S M
Sushilkumar Sati, Nitin Veer, V S Bhosale, S H Bodhankar, S L Mahadik, K R Kadam, S S |
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| Date |
2010-06-01T04:58:35Z
2010-06-01T04:58:35Z 2005-11 |
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/9233 |
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| Description |
2295-2300
7-Hydroxy-4-methylchromene-2-one <b style="">1</b> when reacted respectively with 2-bromo-1-chloroethane and 3-bromo-1-chloropropane in acetonitrile and in the presence of anhydrous K<sub>2</sub>CO<sub>3</sub> yields 7-alkoxy-4-methylchromene-2-ones <b style="">2a,b</b>. Compounds <b style="">2a,b</b> when refluxed with various arylpiperazines in toluene and in the presence of triethylamine yield the title compounds, 7-[(4-substituted phenyl-piperazin-1-yl)-alkoxyl]-4-methylchromen-2-ones <b style="">3a-j</b>.Their atypical antipsychotic activity have been evaluated by their ability to inhibit apomorphine induced climbing behavior (D<sub>2</sub> antagonism) and to inhibit the 5–HTP induced head twitches in albino mice (5-HT<sub>2A</sub> antagonism) alongwith catalepsy studies. All the compounds inhibit apomorphine induced climbing behavior and 5-HTP induced head twitches. The SAR studies reveal that methyl group in the phenyl ring of piperazine and the chain length (n=3) gives more dopaminergic and serotonergic antagonistic activity, while dichlorophenyl piperazines have less dopaminergic and serotonergic antagonistic activity. <b style="">3f</b> and <b style="">3g</b> have been found to have significant atypical behaviour. |
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| Language |
en_US
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| Publisher |
CSIR
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| Relation |
<b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D // A 61 P/28</b>
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| Source |
IJC-B Vol.44B(11) [November 2005]
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| Subject |
Substituted methylchromenones
antipsychotics pharmacological evaluation dichlorophenyl piperazines |
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| Title |
7-[(4-Substituted phenyl-piperazin-1-yl)-alkoxyl]-4-methylchromene-2-ones as potential atypical antipsychotics: Synthesis and pharmacological evaluation
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| Type |
Article
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