A novel composition of bioactive glass with potent haemostatic action and antibacterial competence
IR@CGCRI: CSIR-Central Glass and Ceramic Research Institute, Kolkata
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| Title |
A novel composition of bioactive glass with potent haemostatic action and antibacterial competence
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| Creator |
Roy, Payal
Saha, Rupam Chakraborty, Jui |
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| Subject |
Engineering Materials
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| Description |
Haemorrhagic bleeding is a crucial area of concern related to military as well as civilian trauma. In recent years, bioactive glass is gaining attention in a number of healthcare applications, including haemostasis. Herewith, we report a unique composition of bioactive glass, 70 SiO2: (30-x-y) CaO: x.Al2O3: y.ZnO, where x = 10–18 mole% and y = 0–8 mole%, (Al-BAG) exhibiting haemostatic property as well as antibacterial activity. The as-prepared glass was characterized using XRD, SEM-EDX, FTIR and TG-DSC along with in-vitro degradation study and biological studies e.g., cytocompatibility, haemocompatibility, in-vitro thrombus formation, in-vitro blood absorption capacity, blood coagulation assays (PT, aPTT), in-vitro antibacterial assay against Staph. aureus as well as in-vivo acute dermal toxicity followed by histopathological analysis) and in-vivo haemostasis efficacy were undertaken. The novel bioactive glass composition exhibits promises to be an efficient haemostatic agent with antibacterial activity.
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| Publisher |
Elsevier
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| Date |
2023-02
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://cgcri.csircentral.net/5397/1/payel.pdf
Roy, Payal and Saha, Rupam and Chakraborty, Jui (2023) A novel composition of bioactive glass with potent haemostatic action and antibacterial competence. Ceramics International, 49 (4). pp. 6389-6400. ISSN 0272-8842 |
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| Relation |
http://cgcri.csircentral.net/5397/
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