Hepatoprotective activity of Ficus semicordata Buch.-Ham. ex Sm. leaves aqueous extract on D-galactosamine induced toxicity in HepG2 cell line
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Hepatoprotective activity of Ficus semicordata Buch.-Ham. ex Sm. leaves aqueous extract on D-galactosamine induced toxicity in HepG2 cell line
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| Creator |
Gupta, Shashi
Ranade, Anagha Gayakwad, Shivani Acharya, Rabinarayan Pawar, Sharad |
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| Subject |
D-galactosamine
Dexamethasone Ficus semicordata Buch. Ham. ex Sm Hepatoprotective HepG2 |
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| Description |
239-243
The leaves of <em>Ficus semicordata </em>Buch-Ham.ex Sm., locally in North India is referred to as <em>Bhumi udumbara </em>have been reported for their traditional use to cure jaundice and various liver ailments. Despite its extensive usage in northeastern states of India, there is a lack of scientific substantiation on the safety and pharmacotherapeutic efficacy. The present study was carried out to evaluate the hepatoprotective activity of <em>F. semicordata </em>(FS) leaves aqueous extract on HepG2 cell line to validate its ethnic claim in the management of liver disorders. D-galactosamine induced HepG2 cell toxicity model was used to evaluate its hepatoprotective activity. The cells were treated with different concentrations of aqueous extracts and dexamethasone as a standard. MTT assay was performed to determine the % inhibition of hepatotoxicity. The result indicates that the toxicity induced by D-galactosamine is reduced by FS aqueous extract group which is better when compared with the standard drug. This study revealed the hepatoprotective potential of <em>F. semicordata </em>on HepG2 cell line<em>. |
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| Date |
2021-02-04T09:31:30Z
2021-02-04T09:31:30Z 2020-12 |
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| Type |
Article
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| Identifier |
0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/56149 |
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| Language |
en_US
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| Relation |
Int. cl. (2015.01)- A61K 36/00, A61K 36/60, A61K 127/00, A61P 1/16
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJNPR Vol.11(4) [December 2020]
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