Isolation, characterization, and biological evaluation of flavonols and 1,2-diphenylethanes from Bauhinia vahlii
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Isolation, characterization, and biological evaluation of flavonols and 1,2-diphenylethanes from Bauhinia vahlii
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| Creator |
Ketha, Alekhya
Vedula, Girija Sastry |
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| Subject |
Anticancer
Anti-gout Anti-inflammatory Antioxidant Bauhinia vahlii Sulforhodamine B assay |
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| Description |
312-319
In this study, three known flavonols, namely kaempferol <strong>(1)</strong>, ombuin <strong>(2)</strong>, and quercetin <strong>(3)</strong>, and three known 1,2-diphenylethanes, namely 5-(2-hydroxyphenethyl)-3-methoxy-2-methylphenol <strong>(4)</strong>, 2-(3,5-dimethoxyphenethyl) phenol <strong>(5)</strong> and 2-(2-hydroxyphenethyl)-4,6-dimethoxyphenol <strong>(6) </strong>from the methanolic extract <strong>(ME)</strong> of <em>Bauhinia vahlii </em>were identified and sucessfully isolated. They were also evaluated for <em>in vitro</em> antioxidant, anti-inflammatory, anti-gout and anticancer effects. Compound <strong>3</strong> (26.00±2.17 µg/mL) showed an almost equivalent IC<sub>50</sub> value of standard drug (25.55±2.80 µg/mL) against superoxide free radicals. Moreover, compound <strong>3</strong> showed significant inhibition of COXs and 5-LOX enzymes, while compounds <strong>1, 2, 4</strong> and <strong>5</strong> exhibited good inhibition of XO enzymes. Except for compound <strong>5</strong>, all compounds showed a significant reduction of cell growth lysis of MCF-7, DLD-1, HeLa, and A549. Besides, all the metabolites and <strong>ME</strong> showed a very weak degree of specificity against NHME, indicates less toxicity to normal cells. The results suggest that <em>B. vahlii </em>can be a favourable natural source for the treatment of oxidative stress, inflammation, gout and cancer, and these actions are linked to the natural active compounds <strong>1, 3,</strong> <strong>4</strong> and <strong>6</strong>. |
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| Date |
2021-02-04T09:06:42Z
2021-02-04T09:06:42Z 2020-12 |
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| Type |
Article
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| Identifier |
0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/56140 |
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| Language |
en_US
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| Relation |
Int. cl. (2015.01)- A61K 36/00, A61K 36/48, A61P, A61P 29/00, A61P 39/06
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJNPR Vol.11(4) [December 2020]
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