n-alkylamino analogs of Vitamin K3: Electrochemical, DFT and anticancer activity of their oxidized and one electron reduced form
IR@CMERI: CSIR- Central Mechanical Engineering Research Institute (CMERI), Durgapur
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Title |
n-alkylamino analogs of Vitamin K3: Electrochemical, DFT and anticancer activity of their oxidized and one electron reduced form
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Creator |
Chandra, Dattatray
Banerjee, Priyabrata Saha, Sourav Kr Bhanda, Sujit Patil, Rajendra Sunita Salunke-Gawalia, Sunita |
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Subject |
Chemistry
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Description |
Synthesis, characterization and anticancer activity of reduced form of n-alkylamino analogs of Vitamin K3 (1Na to 8Na) are undertaken. Molecular structure and molecular association of oxidized form of 2-ethylamino-3-methyl-1,4-naphthoquinone (2) and 2-hexylamino-3-methyl-1,4-naphthoquinone (6) were studied by single crystal X-ray analysis. 2 crystallize in monoclinic C2/c and 6 in P21 space group. The reduced form of eight homologated analogs of 2-(n-alkylamino)-3-methyl-1,4-naphthoquinone (1Na to 8Na) were synthesized using sodium metal as reductant at 0 °C in methanol. The formations of naphthosemiquinone radical in 1 to 6 have been confirmed from their EPR spectra. Polycrystalline powder X-band EPR spectra of 1 to 6 shows signals ∼2.0020 ± 0.0026 at 133 K. Anticancer activity of 2-(n-alkylamino)-3-methyl-1,4-naphthoquinone (1Na to 8Na) and one electron reduced forms have been evaluated against breast cancer (HeLa) cell line, 1 and 1Na showed promising anticancer activity.
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Publisher |
Elsevier
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Date |
2019-03-05
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Type |
Article
PeerReviewed |
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Identifier |
Chandra, Dattatray and Banerjee, Priyabrata and Saha, Sourav Kr and Bhanda, Sujit and Patil, Rajendra and Sunita Salunke-Gawalia, Sunita (2019) n-alkylamino analogs of Vitamin K3: Electrochemical, DFT and anticancer activity of their oxidized and one electron reduced form. Journal of Molecular Structure, 1179. pp. 443-452.
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Relation |
http://cmeri.csircentral.net/652/
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