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<i>Spirulina platensis</i> protects neurons via suppression of glial activation and peripheral sensitization leading to restoration of motor function in collagen-induced arthritic rats

IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)

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Title <i>Spirulina platensis</i> protects neurons via suppression of glial activation and peripheral sensitization leading to restoration of motor function in collagen-induced arthritic rats
 
Creator Patro, Nisha
Sharma, Arpita
Kariaya, Keerti
Patro, Ishan
 
Subject Collagen-induced arthritis
Microglia
Neuroprotection
Spinal cord
<i>Spirulina platensis</i>
 
Description 739-748
<i>Spirulina</i> <i style="">platensis</i> treatment (400 mg kg<sup>-1</sup> for 25 days) effectively suppressed peripheral sensitization via modulation of glial activation and improved motor coordination and restoration of functional motor activity in collagen-induced arthritic rats. <i>Spirulina</i> treatment also resulted in an appreciable reduction of the NF200 accumulation in the spinal cord neurons of arthritic rats. This is indicative of neuroprotective action of <i>S.</i> <i style="">platensis</i> against glutamate excitotoxicity-induced central sensitization produced by the peripheral joint inflammation in the collagen-induced arthritis. The results suggest that effects of <i>S.</i> <i style="">platensis</i> may be due to its counter regulation of spinal glial activation and could be a potential strategy for the treatment of arthritis.
 
Date 2011-10-11T05:23:52Z
2011-10-11T05:23:52Z
2011-10
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://hdl.handle.net/123456789/12862
 
Language en_US
 
Rights <img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
 
Publisher NISCAIR-CSIR, India
 
Source IJEB Vol.49(10) [October 2011]