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Tocotrienols: The lesser known form of natural vitamin E

IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)


Field	Value

Title	Tocotrienols: The lesser known form of natural vitamin E

Creator	Patel, Viren Rink, Cameron Khanna, Savita Sen, Chandan K

Subject	Arteriogenesis MMP2 Neuroprotection TIMP1 Tocotrienols Vitamin E

Description	732-738 A recent and growing body of research has shown that members of this vitamin E family posses unique biologic functions. Tocotrienols have garnered much of this recent attention, and in particular a-tocotrienol has been shown to be the most potent neuroprotective form of vitamin E. Protection exclusively mediated through tocotrienols has been arbitrated to many mechanisms including inhibition of 12-LOX, c-Src, PLA<sub>2</sub> and through up-regulation of MRP1. Further, tocotrienols have recently been shown to induce arteriogenesis through induction of TIMP1 and decreased activation of MMP2. However, the unique therapeutic potential of tocotrienols is not limited to neuroprotection. Tocotrienols have been shown to have molecular targets including: apoptotic regulators, cytokines, adhesion molecules, enzymes, kinases, receptors, transcription factors, and growth factors. In spite of this large and unique therapeutic potential, scientific literature on tocotrienols only accounts for approximately 1% of vitamin E research. Given the potential of tocotrienols and relatively scant literature, further investigation is warranted.

Date	2011-10-11T05:23:17Z 2011-10-11T05:23:17Z 2011-10

Type	Article

Identifier	0975-1009 (Online); 0019-5189 (Print) http://hdl.handle.net/123456789/12861

Language	en_US

Rights	<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>

Publisher	NISCAIR-CSIR, India

Source	IJEB Vol.49(10) [October 2011]