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Synthesis of some 3-(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)-1-arylprop-2-en-1-ones and 1,5-bis(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)pent-1,4-diene-3-ones and their antimicrobial activity

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Title Synthesis of some 3-(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)-1-arylprop-2-en-1-ones and 1,5-bis(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)pent-1,4-diene-3-ones and their antimicrobial activity
 
Creator Rani, Archna
Jain, Sapna
Dureja, Prem
Kumar, Rita
Kumar, Anil
 
Subject Chalcone
Antibacterial agent
Antifungal agent
MIC
<img src='http://www.niscair.res.in/jinfo/Alpha.gif' border=0>, <img src='http://www.niscair.res.in/jinfo/Beta.gif' border=0>-unsaturated carbonyl compounds
 
Description 1524-1531
New 3-(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)-1-arylprop-2-en-1-ones (<b style="">4a-n</b>) and 1,5-bis(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)pent-1,4-diene-3-ones (<b style="">4o-r</b>) have been synthesized by using aryl-5-chloro-4-formyl-1,2-pyrazoles (<b style="">2a-d</b>) as key intermediate, prepared by Vilsmeir-Haack reaction of pyrazolones. The compounds have been screened against multihost plant pathogenic fungi <i>Macrophomina phaseolina</i><i style=""> </i>and <i style="">Sclerotium rolfsii</i> and human pathogenic bacteria MTCCB 96 <i style="">Staphylococcus aureus</i>, MTCCB 1610 <i style="">Escherichia coli</i>, clinical isolate <i style="">Citrobacter Sp. </i>and <i style="">Enterococcus faecium</i>. Some compounds have shown promising activity against these microbes. Regression analysis has also been done for relationship between antifungal activity and concentra­tion of compounds.
 
Date 2011-10-10T11:21:40Z
2011-10-10T11:21:40Z
2011-10
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/12858
 
Language en_US
 
Rights <img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.50B(10) [October 2011]