Synthesis and antimicrobial activity of thiazolidinone norfloxacin hybrids
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Synthesis and antimicrobial activity of thiazolidinone norfloxacin hybrids
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| Creator |
Kumar, Vikas
Kumar, Ashok Sharma, Shalabh Singh, Netra Pal |
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| Subject |
Quinoline
Schiff base Thiazolidinone Antibacterial activity Antifungal activity |
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| Description |
1496-1503
A new series of 1-ethyl-6-fluoro-7-piperazinyl-4-oxo-3-(substitutedarylidinylcarboxy-hydrazido)quinolines <b style="">3-7 </b>and 1-ethyl-6-fluoro-7-piperazinyl-4-oxo-3-(2¢-substitutedaryl-4¢-oxo-1¢,3¢-thiazolidin-3¢-yl)aminocarboxyquinolines <b style="">8-12</b> have been synthesized in order to determine their antimicrobial activities and feasible structure-activity relationships. The synthesized compounds and reference drugs have been tested <i style="">in vitro</i> against various strains of bacteria: <i>E. coli ATCC 25922, B. subtilis ATCC 1633</i> and <i>S. aureus ATCC 25923</i> and the fungi: <i>C. albicans ATCC 2091, A. niger ATCC 9029</i> and <i>C. krusei ATCC 6258.</i> Microbiological results showed that the synthesized compounds possessed a broad spectrum of antimicrobial activity against the microorganisms tested. 1-Ethyl-6-fluoro-7-piperazinyl-4-oxo-3-[2¢-(<i style="">o</i>-methoxyphneyl)-4¢-oxo-1¢,3¢-thiazolidin-3¢-yl)aminocarboxyquinoline <b style="">10</b> has displayed more potent antibacterial activity as compared to standard drug, chloroamphenicol and rest of the compounds of this series. This compound has also exhibited significant antifungal activities, which is not more than that of fluconazole. The structural assignments of newly synthesized compounds are based on IR, <sup>1</sup>H NMR, mass spectral studies and elemental analysis. |
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| Date |
2011-10-10T11:18:45Z
2011-10-10T11:18:45Z 2011-10 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/12853 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.50B(10) [October 2011]
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