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Synthesis and antibacterial activity of some new spiro[pyrano[2,3-<i style="">f</i>]chromen-2,1'-cycloalkan]-4-ones and 1'-alkylspiro[pyrano[2,3-<i style="">f</i>]chromen-2,4'-piperidin]-4-ones

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Field	Value

Title	Synthesis and antibacterial activity of some new spiro[pyrano[2,3-<i style="">f</i>]chromen-2,1'-cycloalkan]-4-ones and 1'-alkylspiro[pyrano[2,3-<i style="">f</i>]chromen-2,4'-piperidin]-4-ones

Creator	Sreenivas, P Reddy, S Satyanarayana Rao, Y Jayaprakash Rao, Ch Prasada Krupadanam, G L David

Subject	Regioselective synthesis [3,3]Sigmatropic shift Pyrano spirochromanones Antibacterial activity

Description	1484-1490 Claisen rearrangement of 7-propargyloxyspirochromanones in <i style="">N,N</i>-diethylaniline affords spiro[pyrano[2,3-<i style="">f</i>]chromen-2,1'-cycloalkan]-4-ones, while 1'-alkylspiro[pyrano[2,3-<i style="">f</i>]chromen-2,4'-piperidin]-4-ones can be synthesized by Claisen rearrangement of 4-propargyloxyresaectophenones followed by cyclization using <i style="">N</i>-subsituted piperidones in ethanol-pyrrolidine. All the compounds have been tested <i style="">in vitro</i> for their antibacterial activity against Gram-positive bacteria <i style="">Bacillus subtilis</i> and <i style="">Staphylococcus aureus</i> and Gram-negative bacteria <i style="">Escherichia coli</i> and <i style="">Pseudomonas aeruginosa</i>. Some of the compounds show moderate to good antibacterial activity.

Date	2011-10-10T11:16:38Z 2011-10-10T11:16:38Z 2011-10

Type	Article

Identifier	0975-0983(Online); 0376-4699(Print) http://hdl.handle.net/123456789/12851

Language	en_US

Rights	<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>

Publisher	NISCAIR-CSIR, India

Source	IJC-B Vol.50B(10) [October 2011]