Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives
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| Creator |
Mariappan, G
Bhuyan, N R Kumar, Pradeep Kumar, Deepak Murali, K |
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| Subject |
Benzimidazole
Analgesic Anti-inflammatory Mannich bases |
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| Description |
1216-1219
[1-(N-substituted amino) methyl]-2-ethyl benzimidazole derivatives <b style="">1-10</b> have been<b style=""> </b>synthesized by the condensation of 2-ethyl benzimidazole with substituted primary and secondary amines. Their structures have been elucidated by UV-Vis, IR, <sup>1</sup>H NMR and mass spectral data. Among the synthesized derivatives <b style="">1, 2, 8, 9</b> and <b style="">10</b> are found to have an effective anti-inflammatory response whereas compounds <b style="">2, 4, 6, 8</b> and <b style="">10</b> have potent analgesic response. There is no significant difference in bioactivity of benzimidazoles derived from secondary and primary amines. All the experimental data were statistically significant at P<0.05 level. |
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| Date |
2011-09-07T08:47:53Z
2011-09-07T08:47:53Z 2011-09 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/12674 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.50B(09) [September 2011]
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