Synthesis and antibacterial activity of some novel <i>N</i>-substituted 3-[4-(1-alkyl/acyl/aroyl-1<i>H</i>-benzimidazol-2-yl)phenyl]acrylate derivatives
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Synthesis and antibacterial activity of some novel <i>N</i>-substituted 3-[4-(1-alkyl/acyl/aroyl-1<i>H</i>-benzimidazol-2-yl)phenyl]acrylate derivatives
|
|
| Creator |
Chaudhari, Raju B
Vaidya, Sanjay D Karale, B K Pawar, P Y Rindhe, Sahebrao S |
|
| Subject |
Benzimidazole
Heck Acrylate Antibacterial |
|
| Description |
1208-1215
Synthesis of a series of novel 3-[4-(1-alkyl/acyl/aroyl-1<i>H</i>-benzimidazol-2-yl)phenyl]acrylate derivatives has been reported. These derivatives are prepared by condensation of <i style="">o</i>-phenylenediamine with 4-bromobenzoic acid to give 2-(4-bromophenyl)-1<i>H</i>-benzimidazole which undergoes Heck reaction with alkyl acrylates to give the above benzimidazole derivatives. Subsequent reactions of these compounds with different types of electrophiles afford a series of the corresponding 1N-substituted alkyl/acyl/aroyl/sulfonyl derivatives. Furthermore, the antibacterial activities of these compounds have been checked against <i style="">Staphylococcus aureus</i> and <i style="">Salmonella typhimurium</i> bacterial strains but the results are found to be disappointing. |
|
| Date |
2011-09-07T08:47:36Z
2011-09-07T08:47:36Z 2011-09 |
|
| Type |
Article
|
|
| Identifier |
0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/12673 |
|
| Language |
en_US
|
|
| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
|
|
| Publisher |
NISCAIR-CSIR, India
|
|
| Source |
IJC-B Vol.50B(09) [September 2011]
|
|