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Design, facile synthesis and biological evaluation of quinazoline containing pyrazolothiazolyl, triazinone and their ethoxyphthalimide derivatives

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Title Design, facile synthesis and biological evaluation of quinazoline containing pyrazolothiazolyl, triazinone and their ethoxyphthalimide derivatives
 
Creator Dangi, Raja Ram
Hussain, Nasir
Joshi, Ajit
Pemawat, Gangotri
Talesara, Ganpat Lal
 
Subject Benzoxazine
Quinazoline
Pyrazole
Schiff base
Bromoethoxyphthalimide
 
Description 1165-1172
A series of 3-(4-substituted benzylidene)-4-N-ethoxyphthalimido-6-phenyl-3,4-dihydro-2<i>H</i>-[1,2,4]triazino[2,3-<i>c</i>]quinazolin-2-one <b style="">6a-d</b> and 3-[3-(4-substituted benzylidene-5-phenyl- 2-N-ethoxyphthalimido-3,3<i style="">a</i>-dihydro-2<i>H</i>-pyrazolo[3,4-<i>d</i>][1,3]thiazol-6(5<i>H</i>)-yl)]-2-phenylquinazolin-4(3<i>H</i>)-one <b style="">11a-d</b> have been designed and synthesized starting from benzoxazine <b style="">1</b>. The structure of all synthesized compounds has been established by IR, <sup>1</sup>H and <sup>13</sup>C NMR and mass spectral studies. These compounds have been screened for antimicrobial activities in order to evaluate the possibility of the derivatives to be used as potential chemotherapeutic agents.
 
Date 2011-09-07T08:40:52Z
2011-09-07T08:40:52Z
2011-09
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/12666
 
Language en_US
 
Rights <img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.50B(09) [September 2011]