Effect of oleic, lauric and myristic acids on phenylephrine-induced contractions of isolated rat vas deferens
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Effect of oleic, lauric and myristic acids on phenylephrine-induced contractions of isolated rat vas deferens
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| Creator |
Arruzazabala, ML
Pérez, Y Ravelo, Y Molina, V Carbajal, D Mas, R Rodríguez, E |
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| Subject |
D-004
Oleic lauric and myristic acids Phenylefrine induced contractions Vas deferens |
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| Description |
684-688
D-004, a lipid extract of <i style="">Roystonea regia </i>fruits that contains oleic, lauric and myristic acids as major components inhibits α1-adrenoreceptors-mediated contractile responses in isolated rat vas deferens and prostate trips; no study has demonstrated a similar effect for oleic, lauric or myristic acids individually. Therefore, the effects of D-004 (250 <img src='/image/spc_char/micro.gif' border=0> g/ml), oleic (100 <img src='/image/spc_char/micro.gif' border=0> g/ml), lauric (50 <img src='/image/spc_char/micro.gif' border=0>g/ml) or myristic (25 <img src='/image/spc_char/micro.gif' border=0>g/mL) acids and their combined effects on phenylephrine (PHE: 10<sup>-7</sup>- 10<sup>-4 </sup>mol/L) induced contractions has been studied. No treatment changed the basal tone of the preparations, but all inhibited PHE-induced contractions. D-004 produced the highest inhibition, followed by lauric acid, which was more effective than myristic and oleic acids against PHE-induced contractions of control group. D-004 and the mixture of the three acids produced similar inhibitions |
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| Date |
2011-08-29T06:41:50Z
2011-08-29T06:41:50Z 2011-09 |
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| Type |
Article
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| Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://hdl.handle.net/123456789/12614 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJEB Vol.49(09) [September 2011]
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