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Effect of combination of thalidomide and sulfasalazine in experimentally induced inflammatory bowel disease in rats

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Title Effect of combination of thalidomide and sulfasalazine in experimentally induced inflammatory bowel disease in rats
 
Creator Prakash, O
Medhi, B
Saikia, UN
Pandhi, P
 
Subject Inflammatory bowel disease
Malondialdehyde
Myeloperoxidase
Sulfasalazine
Thalidomide
Tumor necrosis factor-<img src='/image/spc_char/alpha.gif' border=0>
 
Description 672-678
Thalidomide provided significant protection against tri nitro benzene sulfonic acid induced colitis. Combination therapy also reduced colonic inflammation and all the biochemical parameters (myeloperoxidase assay, malondialdehyde assay and tumor necrosis factor-<img src='/image/spc_char/alpha.gif' border=0> , estimation) were significant as compared to control as well as thalidomide alone treated group. Combination therapy showed additive effect of thalidomide which restored lipid peroxidation as well as reduced myeloperoxidase and TNF-<img src='/image/spc_char/alpha.gif' border=0> towards the normal levels. Morphological and histological scores were significantly reduced in combination groups. In experimental model of colitis, oral administration of thalidomide (150 mg/kg) alone as well as its combination with sulfasalazine (360 mg/kg) significantly reduced the colonic inflammation. The results indicate the additive effect of thalidomide with sulfasalazine in rat colitis model which requires further confirmation in human studies.
 
Date 2011-08-29T06:40:38Z
2011-08-29T06:40:38Z
2011-09
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://hdl.handle.net/123456789/12612
 
Language en_US
 
Rights <img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
 
Publisher NISCAIR-CSIR, India
 
Source IJEB Vol.49(09) [September 2011]