Ru(III)(EDTA) mediated S-nitrosylation of cysteine by nitrite
IR@CMERI: CSIR- Central Mechanical Engineering Research Institute (CMERI), Durgapur
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| Title |
Ru(III)(EDTA) mediated S-nitrosylation of cysteine by nitrite
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| Creator |
Chatterjee, D.
Jaiswal, N. Schmeisser, M. van Eldik, R. |
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| Subject |
Chemistry
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| Description |
Reported here is the first example of a ruthenium(iii) complex [Ru(III)(EDTA)(H2O)](-) (EDTA(4-) = ethylenediaminetetraacetate) that mediates S-nitrosylation of cysteine in the presence of nitrite at pH 4.5 (acetate buffer) and results in the formation of [Ru(III)(EDTA)(SNOCy)](-). The kinetics of the reaction was studied by stopped-flow and rapid-scan spectrophotometry as a function of [Cysteine], [NO2(-)] and pH (3.5-8.5). Formation of [Ru(III)(EDTA)(SNOCy)](-), the product of the S-nitrosylation reaction, was identified by ESI-MS experiments. A working mechanism in agreement with the spectroscopic and kinetic data is presented.
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| Publisher |
Royal Society of Chemistry
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| Date |
2014
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| Type |
Article
PeerReviewed |
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| Identifier |
Chatterjee, D. and Jaiswal, N. and Schmeisser, M. and van Eldik, R. (2014) Ru(III)(EDTA) mediated S-nitrosylation of cysteine by nitrite. Dalton Transactions, 43 (48). pp. 18042-18046.
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| Relation |
http://cmeri.csircentral.net/336/
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