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Signaling through NOD-2 and TLR-4 Bolsters the T cell Priming Capability of Dendritic cells by Inducing Autophagy.

IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh


Field	Value

Title	Signaling through NOD-2 and TLR-4 Bolsters the T cell Priming Capability of Dendritic cells by Inducing Autophagy.

Creator	Khan, Nargis Vidyarthi, Aurobind Pahari, Susanta Negi, Shikha Aqdas, Mohammad Nadeem, Sajid Agnihotri, Tapan Agrewala, J N

Subject	QR Microbiology

Description	T cells play a cardinal role in mediating protection against intracellular pathogens like Mycobacterium tuberculosis (Mtb). It is important to understand the factors that govern the T cell response; thereby can modulate its activity. Dendritic cells (DCs) are the major player in initiation and augmentation of T cell response. Targeting DCs to induce their optimum maturation and activation can lead to a better T cell response. Interestingly, we observed that combinatorial signaling of DCs through NOD-2 and TLR-4 fortified better yield of IL-12p40/70, IL-6 and IFN-γ and upregulated the expression of CD40, CD80 and CD86 costimulatory molecules. Further, we noticed improved phagocytic capabilities of DCs. Furthermore, NOD-2 and TLR-4 induced autophagy in DCs, which enhanced the activation of T cells. This study signifies that NOD-2 and TLR-4 exhibit synergism in invigorating the activity of DCs. Consequently, this strategy may have significant immunotherapeutic potential in bolstering the function of DCs and thus improving the immunity against pathogens.

Publisher	NPG

Date	2016

Type	Article PeerReviewed

Relation	http://www.nature.com/articles/srep19084 http://crdd.osdd.net/open/1812/

Identifier	Khan, Nargis and Vidyarthi, Aurobind and Pahari, Susanta and Negi, Shikha and Aqdas, Mohammad and Nadeem, Sajid and Agnihotri, Tapan and Agrewala, J N (2016) Signaling through NOD-2 and TLR-4 Bolsters the T cell Priming Capability of Dendritic cells by Inducing Autophagy. Scientific reports, 6. p. 19084. ISSN 2045-2322