Synthesis of a pentasaccharide repeating unit of the O-specific polysaccharide from the lipopolysaccharide of Providencia alcalifaciens O28
IR@CDRI: CSIR-Central Drug Research Institute, Lucknow
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Creator |
Mandal, P K
Chheda, P R |
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Date |
2015-03-24T10:13:24Z
2015-03-24T10:13:24Z 2015 |
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Identifier |
Tetrahedron Letters, 2015, 56(7), 900–902
http://hdl.handle.net/123456789/1441 |
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Description |
A straightforward convergent synthetic strategy has been developed for the synthesis of the pentasaccharide repeating unit of the O-specific cell wall lipopolysaccharide of Providencia alcalifaciens O28. The target pentasaccharide has been synthesized in excellent yield using a [3+2] block glycosylation approach with minimum number of steps. Here H2SO4-silica has been used successfully as a promoter for glycosylation reaction. All glycosylation steps are high yielding and stereoselective.
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Format |
265520 bytes
application/pdf |
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Language |
en
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Relation |
CSIR-CDRI Communicatiobn No.8878
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Subject |
Providencia alcalifaciens
Oligosaccharide Glycosylation Lipopolysaccharide H2SO4–silica |
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Title |
Synthesis of a pentasaccharide repeating unit of the O-specific polysaccharide from the lipopolysaccharide of Providencia alcalifaciens O28
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Type |
Article
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